File this one under, ‘Things That Make You Go Hmm’. Dead Butt Syndrome is actually real. You might be sitting there going, ‘Come on, Heather. TMI.’ But have you ever heard the phrase ‘sitting is the new smoking’. There’s real clinical research about how being sedentary and sitting for too long takes a toll on your well-being. reports sitting for long stretches of time can increase a person’s risk for diabetes, heart disease, and even cancer. And it doesn’t take a rocket scientist to draw the conclusion that staying planted on your booty all day can lead to weight gain.